Swapping out 2nd HD to bigger Drive, Easy as copy and paste?

I have 3 HDD in my gaming PC:
120 GB SSD
128 GB Raptor
320 GB WD Storage Drive

OS, a few games and a few small programs on the SSD.
Steam Games and all other programs are on the Raptor.
The WD is for downloading and media.

They're all about 85% full. I want to replace the raptor with a bigger one so I can install more of my steam games mainly. Since there's no OS stuff on that drive, is it as easy as copying all the stuff from one raptor to the new raptor. Or will some programs I have installed on there "break". I know of one game "rfactor", that may not recognize the new drive, but their protection might be using the windows registry, which is on the SSD.

Thanks, Ryan