Computer peripherals keep breaking/cutting out.

Hello,

Since about 4 months ago I've been having a constant issue with my computer. I would be playing a game (dirty bomb, csgo, arma, runescape) and randomly my mouse and keyboard will lose power and the lights will start flashing. The only solution I've found after this point is restarting the computer. My mouse also randomly drops out every now and again.
Any solutions will be greatly appreciated. :)

Here is a video:
https://youtu.be/nFPHp0SJP0I